At Bartlett, Shali Simpson had 11 points and five assists as the Lady Buffs routed Bartlett in their season opener.
Rebecca Horton added eight points and 15 rebounds, and Clarissa Carranco had nine points and nine rebounds for Florence, which returns to action Tuesday at Troy.
The Lady Buffs took control in the second quarter, outscoring the Lady Bulldogs 21-3 for a 26-5 halftime lead.
Florence returns to action Tuesday at Troy.
Florence girls 46, Bartlett 18