At Hamilton, the Lady Hornets struggled to score points in a season-opening loss on the road.
Meghan Haferkamp led Gatesville with five points, while teammates Kayla McGiboney, Corie Tunnel and Randi Farney each finished with four points.
Adding to their offensive struggles, the Lady Hornets are inexperienced at point guard, using three freshmen to help fill the void left due to an ACL injury to senior Sarah Latham.
Gatesville will look to earn its first win of the season Tuesday, when it hosts Marlin.
Hamilton girls 34, Gatesville 25