Florence's C.J. Giddens ran for 107 yards and passed for 152, but the Buffaloes lost their season opener 34-29 at home Friday against Rosebud-Lott.
Giddens scored on a 25-yard run, and tossed touchdown passes of 23 and 25 yards to Kelby Vaughn and Ronnie Zuniga, respectively.
Landon Byrne had Florence's longest scored, a 39-yard touchdown run.
Rosebud-Lott finished with 437 rushing yards on 52 carries.