On TV, Sunday nights are often blocked off for highbrow shows: “Game of Thrones,” “Homeland,” “The Walking Dead,” “The Good Wife,” “Downton Abbey” and many more. Ever since “The Sopranos” made a splash on Sundays, the time slot quickly became the sign of a prestige series.

Chelsea Handler, formerly host of the E! talk show “Chelsea Lately” and author of books including “My Horizontal Life: A Collection of One-Night Stands” and “Are You There, Vodka? It’s Me, Chelsea,” stops on the way to her upcoming Netflix-based talk show as the host and partial subject of a…