• October 21, 2014

U.S. doctors urge wider use of cholesterol drugs

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Posted: Wednesday, November 13, 2013 4:30 am | Updated: 10:44 pm, Mon Nov 18, 2013.

The nation’s first new guidelines in a decade for preventing heart attacks and strokes call for twice as many Americans — one-third of all adults — to consider taking cholesterol-lowering statin drugs.

The guidelines, issued Tuesday by the American Heart Association and American College of Cardiology, are a big change. They use a new formula for estimating someone’s risk that includes many factors besides cholesterol, the main focus now. They take aim at strokes, not just heart attacks. And they set a lower threshold for using medicines to reduce risk.

The definition of high cholesterol isn’t changing, but the treatment goal is. Instead of aiming for a specific number, using whatever drugs get a patient there, the advice stresses statins such as Lipitor and Zocor and identifies four groups of people they help the most.

“The emphasis is to try to treat more appropriately,” said Dr. Neil Stone, the Northwestern University doctor who headed the cholesterol guideline panel. “We’re going to give statins to those who are the most likely to benefit.”

Doctors said the new approach will limit how many people with low heart risks are put on statins simply because of a cholesterol number. Yet under the new advice, 33 million Americans — 44 percent of men and 22 percent of women — would meet the threshold to consider taking a statin.

Under the current guidelines, statins are recommended for only about 15 percent of adults.

Some doctors not involved in writing the guidance worry that it will be tough to understand.

“It will be controversial, there’s no question about it. For as long as I remember, we’ve told physicians and patients we should treat their cholesterol to certain goal levels,” said the Cleveland Clinic’s Dr. Steven Nissen. “There is concern that there will be a lot of confusion about what to do.”

The government’s National Heart, Lung and Blood Institute appointed expert panels to write the new guidelines in 2008, but in June said it would leave drafting them to the Heart Association and College of Cardiology. New guidelines on lifestyle and obesity also came out Tuesday, and ones on blood pressure are coming soon.

Heart disease is the leading cause of death worldwide. High cholesterol leads to hardened arteries that can cause a heart attack or stroke. Most cholesterol is made by the liver, so diet changes have a limited effect on it.

Millions of Americans take statins, which reduce cholesterol dramatically and have other effects that more broadly lower the chances of heart trouble.

The patents on Lipitor, Zocor and other statins expired, and they are widely available in generic versions for as little as a dime a day. One that is still under patent protection is AstraZeneca’s Crestor, which had sales of $8.3 billion in 2012.

Despite a small increased risk of muscle problems and accelerating diabetes in patients already at risk for it, statins are “remarkably safe drugs” whose benefits outweigh their risks, said Dr. Donald Lloyd-Jones, preventive-medicine chief at Northwestern.

Current guidelines say total cholesterol should be under 200, and LDL, or “bad cholesterol,” under l00. Other drugs such as niacin and fibrates are sometimes added to statins to try to reach those goals, but studies show they don’t always lower the chances of heart problems.

“Chasing numbers can lead us to using drugs that haven’t been proven to help patients. You can make someone’s lab test look better without making them better,” said Yale University cardiologist Dr. Harlan Krumholz, who has long urged the broader risk approach the new guidelines take.

Aspirin — widely used to lower the risk of strokes and heart attacks — is not addressed in the guidelines. And many drugs other than statins are still recommended for certain people, such as those with high triglycerides.

© 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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1 comment:

  • Dr Strangelove posted at 10:59 am on Wed, Nov 13, 2013.

    Dr Strangelove Posts: 510

    In 1994 I had high cholesterol I took a drug to lower it for about a year. During that year I totally changed my diet. I stopped eating junk/fried foods, I eat brown rice, bake potatoes, steamed vegetables, boneless skinless chicken breasts, skim milk etc. I lowered my cholesterol through diet and no longer take the drug. So people check with your doctor but you can control your cholesterol with diet and don’t need the drugs.

     

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